In　this　article,　our　main　goal　is　to　establish　a　novel　functional　poly　(amidoamine)　dendrimer　with　cyclodextrin　core　for　further　application　in　the　complex　drugs　delivery　system.　Therefore,　the　different　generation　poly(amidoamine)　dendrimers　with　a　core　of　cyclodextrin　(CP)　were　synthesized　via　the　divergent　approach　by　using　(aminoethyl)　amino-beta-cyclodextrin　(EDA-beta-CD)　and　methyl　acrylate　as　the　starting　materials.　Then　the　CP　modified　by　salicylaldehyde　(CPS)　having　different　generations　was　obtained　by　co　molecular　interaction　of　various　dendrimers　with　bovine　serum　albumin　(BSA)　was　a　investigated　by　ndensation　reaction.　All　of　them　were　characterized　by　H-1-NMR,　C-13-NMR　and　IR.　The　molecular　interaction　between　various　dendrimers　with　bovine　serum　albumin　(BSA)　was　investigated　by　fluorescence　in　buffer　solution　(pH　=　7.4).　The　results　show　that　BSA　fluorescence　was　strongly　quenched　by　the　two　types　of　dendrimers.　As　shown　by　K-sv　values,　the　quenching　mechanism　was　a　static　quenching　one,　and　the　data　increase　with　the　increases　of　generation.　In　addition,　the　two　types　of　dendrimers　(CP　and　CPS)　possess　higher　interaction　ability　than　the　corresponding　dendrimers　with　an　ethylenediamine　core,which　indicates　that　the　dentrimers　with　a　core　of　cyclodextrin　and　end　groups　modified　by　salicylaldehyde　can　enhance　the　ability　of　interaction　between　dendrimers　and　BSA.