Pillararenes　trimer　with　particularly　designed　structural　geometry　and　excellent　capacity　of　recognizing　guest　molecules　is　a　very　efficient　and　attractive　building　block　for　the　fabrication　of　advanced　self-assembled　materials.　Pillararenes　trimers　could　be　prepared　via　both　covalent　and　noncovalent　bonds.　The　classic　organic　synthesis　reactions　such　as　click　reaction,　palladium-catalyzed　coupling　reaction,　amidation,　esterification,　and　aminolysis　are　employed　to　build　covalent　bonds　and　integrate　three　pieces　of　pillararenes　subunits　together　into　the　＂star-shaped＂　trimers　and　linear　foldamers.　Alternatively,　pillararenes　trimers　could　also　be　assembled　in　the　form　of　host-guest　inclusions　and　mechanically　interlocked　molecules　via　noncovalent　interactions,　and　during　those　procedures,　pillararenes　units　contribute　the　cavity　for　recognizing　guest　molecules　and　act　as　a　＂wheel＂　subunit,　respectively.　By　fully　utilizing　the　driving　forces　such　as　host-guest　interactions,　charge　transfer,　hydrophobic,　hydrogen　bonding,　and　C-H＜sup＞…＜/sup＞π　and　π-π　stacking　interactions,　pillararenes　trimers-based　supramolecular　self-assemblies　provide　a　possibility　in　the　construction　of　multi-dimensional　materials　such　as　vesicular　and　tubular　aggregates,　layered　networks,　as　well　as　frameworks.　Interestingly,　those　assembled　materials　exhibit　interesting　external　stimuli　responsiveness　to　e.g.,　variable　concentrations,　changed　pH　values,　different　temperature,　as　well　as　the　addition/removal　of　competition　guests　and　ions.　Thus,　they　could　further　be　used　for　diverse　applications　such　as　detection,　sorption,　and　separation　of　significant　multi-analytes　including　metal　cations,　anions,　and　amino　acids.