Partitions　are　widely　installed　in　commercial　buildings,　which　could　block　the　supplied　air　and　then　have　an　influence　on　indoor　environment.　This　paper　mainly　aims　to　investigate　the　performances　of　mixing　ventilation　(MV),　displacement　ventilation　(DV),　and　stratum　ventilation　(SV)　in　a　partitioned　office　via　computational　fluid　dynamics　(CFD).　A　simulation　model　was　established　and　validated　through　experimental　measurement.　The　distributions　of　temperature　and　carbon　dioxide　(CO2)　concentration,　predicted　mean　vote　index　(PMV),　and　local　mean　age　of　air　were　examined.　The　results　indicated　that　the　partition　had　significant　effects　on　ventilation　performances　under　DV,　wherein　the　obstacle　effect　of　the　partition　could　lead　to　both　heat　and　contaminant　accumulations　around　the　occupant,　and　then　resulted　in　a　risk　of　thermal　discomfort　as　well　as　a　reduction　of　inhaled　air　quality.　In　contrary　to　DV,　the　indoor　air　quality　and　thermal　comfort　of　occupant　were　slightly　influenced　by　the　partition　under　MV　and　SV.　With　the　same　air　change　rate　and　supply　air　temperature,　SV　exhibited　a　better　cooling　effect　and　ensured　a　higher　inhaled　air　quality　than　MV　and　DV　in　a　partitioned　office.　The　results　of　this　study　could　help　to　provide　a　reference　for　the　design　of　the　air-conditioning　system　in　a　space　with　partition.　©　2020,　Springer　Nature　Singapore　Pte　Ltd.