The　tumor/infection-impaired　skin　regeneration　is　still　a　challenge　and　the　single　modal　therapy　strategy　is　usually　inefficient.　Herein,　a　multimodal　tumor　therapy　and　antiinfection　method　based　on　the　conductive　multifunctional　poly(glycerol-amino　acid)-based　scaffolds　is　reported.　The　multifunctional　conductive　scaffolds　were　formed　through　the　crosslinking　between　branched　poly(glycerol-amino　acid),　polypyrrole@polydopamine　(PPy@PDA)　nanoparticles　and　aldehyde　F127　(PGFP　scaffolds).　PGFP　scaffolds　possessed　controlled　electrical　conductivity,　skin-adhesive　behavior,　broad-spectrum　antibacterial　activity,　photothermal-responsive　drug　release　and　good　cytocompatibility.　Thus,　PGFP　scaffolds　demonstrated　the　significant　photothermo-chemo　tumor　and　multidrug　resistant　infection　therapy　in　vitro　and　in　vivo,　while　promoting　granulation　tissue　formation,　collagen　deposition,　vascular　endothelial　differentiation　and　accelerated　skin　regeneration.　This　work　also　firstly　demonstrated　the　important　role　of　multifunctional　conductive　PPy@PDA　nanoparticles　in　tumor/infection-impaired　skin　multimodal　therapy.　This　study　suggests　that　efficient　multimodal　therapy　on　diseased-impaired　skin　could　be　achieved　through　optimizing　the　structure　and　multifunctional　properties　of　biomaterials.　©　2020　Elsevier　Ltd