In　deep　hole　machining,　drilling　parameters　for　twist　drills　have　an　important　impact　on　tool　life　and　economic　efficiency.　In　order　to　explore　the　influence　of　drilling　parameters　on　twist　drills,　this　paper　established　a　drilling　model　for　twist　drill　45　steel,　orthogonal　experiments　were　designed.　AdvantEdge　FEM　finite　element　software　was　used　to　simulate　the　drilling　force,　torque　and　drilling　temperature.　The　drilling　force,　torque　and　drilling　temperature　were　analyzed　by　using　the　finite　element　simulation　value　as　the　orthogonal　experimental　value.　In　order　to　ensure　that　the　simulation　results　have　certain　reference　value,　the　drilling　experiment　was　carried　out　in　order　to　ensure　the　simulation　results　have　reference　value.　Finally,　the　optimal　combination　of　drilling　parameters　was　obtained.　©　2020　Trans　Tech　Publications　Ltd,　Switzerland.