Silk　fibroin　(SF)　based　hydrogels　possess　great　potential　in　wound　healing.　However,　they　have　limitations　as　wound　dressings,　such　as　long-gelation　time,　high　temperature　or　organic　solvent-assisted　treatment,　and　lack　of　self-healing　property.　In　this　study,　a　supramolecular　hydrogel　based　on　SF,　acryloyl-β-cyclodextrin　(Ac-CD)　and　2-hydroxyethyl　acrylate　was　developed　through　a　facile　method　by　photo-polymerization　of　acrylate　under　UV　irradiation,　and　showed　enhanced　performance　as　wound　dressing　than　commercial　dressing.　This　SF　based　hydrogel　was　confirmed　to　be　dually　crosslinked　by　host–guest　interaction　and　hydrophobic　β-sheet　conformation,　and　demonstrated　improved　mechanical　properties,　long-term　stability,　rapid　self-healing　behavior,　injectability,　and　good　biocompatibility,　benefiting　its　application　as　wound　dressing.　Moreover,　as　a　drug　carrier　owing　abundant　CDs,　the　hydrophobic　drug　curcumin　with　antioxidant　and　anti-inflammatory　activity　was　loaded　in　SF-based　hydrogel,　accompanying　with　a　controlled　and　sustained　release　profile,　therewith　boosting　better　wound　healing　performance　with　generating　higher　granulation　tissue　thickness,　collagen　disposition,　upregulating　vascular　endothelial　growth　factor　(VEGF),　and　decreasing　inflammatory　response　in　a　full-thickness　skin　defect　model.　In　conclusion,　this　novel　self-healing　SF-based　hydrogel　is　of　great　value　in　wound　healing　and　enriches　the　fabrication　methodology　of　SF-based　self-healing　biomaterials　as　well.　©　2020　Elsevier　B.V.