The　efficient　cutaneous　wound　healing　accompanied　with　the　enhanced　skin　appendage　regeneration　is　still　a　challenge.　The　bacterial　infection　and　excessive/prolonged　inflammation　inhibit　wound　healing　process　and　result　in　the　scar　formation.　Herein,　we　reported　an　anti-inflammatory　polycitrate-polyethyleneimine-Ibuprofen　(PCEI)　and　multifunctional　PCEI-based　F127-ε-polypeptide-alginic　(FEA)　dressing　(FEA-PCEI)　for　accelerating　wound　healing　and　hair　follicle　neogenesis.　PCEI　showed　the　excellent　anti-inflammation　function　through　stimulating　macrophage　towards　anti-inflammatory　M2　subtype　polarization.　The　FEA-PCEI　dressing　showed　the　temperature-response　gelation,　injectability,　robust　antibacterial　activity,　light-damage-resistant,　homeostasis　ability,　and　good　cytocompatibility.　The　optimized　dosage　of　FEA-PCEI　dressing　could　significantly　accelerate　wound　healing　with　anti-infection　ability,　reduce　the　scar　formation,　and　promote　the　hair　follicle　neogenesis.　This　study　provided　a　wound-repairing　strategy　through　regulating　the　phenotype　of　immune　cells　by　the　designing　bioactive　multifunctional　biomaterials.