The　off-design　performance　of　partial　heating　carbon　dioxide　power　cycle　driven　by　the　waste　heat　of　gas　turbine　is　quantitatively　analyzed　in　this　paper.　Firstly,　multi-objective　optimization　is　carried　out　from　the　perspective　of　thermodynamics　and　economics　to　determine　the　cycle　parameters　in　design　phase.　The　heat　exchanger　and　turbomachinery　are　preliminarily　designed　based　on　the　optimization　results.　Then,　the　performance　of　partial　heating　cycle　under　off-design　conditions　is　investigated　considering　variable　flue　gas　parameters　and　ambient　temperature.　The　results　indicate　that　the　net　power　output　would　increase　by　0.62　MW　on　average　as　the　mass　flow　rate　of　flue　gas　increases　by　5　kg/s.　For　every　10　°C　increase　in　flue　gas　inlet　temperature,　the　net　output　power　will　increase　by　0.29　MW.　However,　the　system　exergy　efficiency　first　increases　then　decreases　as　the　mass　flow　rate　of　flue　gas　increases.　The　net　power　output　and　system　exergy　efficiency　show　descending　tendency　as　ambient　temperature　increases.　In　summary,　the　regulation　of　cycle　maximum　pressure　should　be　highlighted　in　response　to　the　variation　of　flue　gas　parameters　while　the　adjustment　of　cycle　minimum　pressure　should　be　emphasized　in　response　to　the　variation　of　ambient　temperature.　©　2021　Elsevier　Ltd