In　the　work,　the　catalytic　performance　and　reaction　mechanism　of　methanol　oxidation　reaction(MOR)　are　studied　for　the　bimetallic　PdxCuy　and　PdxNiy　catalysts　in　alkaline　solution.　The　results　reveal　that　the　Pd1Ni1/C　and　Pd1Cu1/C　bimetallic　catalysts　exhibit　high　catalytic　activity　4.1　and　3.9　times　higher　than　that　of　the　commercial　Pd/C　catalyst.　Combined　with　the　X-ray　diffraction　(XRD),　High-resolution　transmission　electron　microscopy(HRTEM)　and　X-ray　photoelectron　spectroscopy　(XPS)　analysis,　the　charge　transfer　between　Pd　and　Cu(or　Ni)　alters　the　electron　density　of　Pd　and　enhances　the　anti-CO　poisoning　ability,　which　is　confirmed　by　DFT　(Density　Functional　Theory)　calculations.　The　CO　binding　energy　is　weakened　on　various　bimetallic　surfaces　compared　with　that　on　Pd(111),　consistent　with　experimental　results.　A　linear　relationship　exists　between　the　CO　binding　energy　and　the　catalytic　activity　on　the　bimetallic　catalysts,　indicating　that　the　CO　binding　energy　may　be　the　potential　descriptor　for　MOR　in　alkaline　media.　©　2020　Hydrogen　Energy　Publications　LLC