In　recent　years,　the　perfluoroketone　(CF100)　has　drawn　much　attention　as　one　of　the　potential　environmental-friendly　gas　to　substitute　SF6　in　power　industry.　CF100performs　well　in　insulation　with　the　low　GWP　of　less　than　1.　In　the　gas-insulated　systems,　the　insulation　gases　will　have　inevitable　and　direct　contact　with　different　solid　surfaces.　The　\alpha-AlO-filled　epoxy　resin　and　AlO　ceramics　always　be　used　as　insulation　materials　in　GIS　and　GIL.　In　this　paper,　the　interaction　between　CF10O　and　\alpha-aluminum　oxide　under　electric　field　was　investigated　by　density　functional　theory　(DFT)　calculations.　Based　on　several　adsorption　structures,　an　electric　field　was　applied　in　Z　direction,　simulating　the　working　condition　of　electrical　apparatuses　in　practical　engineering.　The　adsorption　energy　and　charge　transfer　have　been　calculated,　and　it　has　been　confirmed　that　the　interaction　of　CsF10O　on　\alpha-AlO　(0001)　surface　belongs　to　chemisorption,　and　the　external　E-field　have　little　impacts　on　the　adsorption　properties　in　practical　engineering,　which　can　provide　basics　for　further　study　on　compatibility　of　the　insulated　gas-solid　systems　and　guidance　for　the　stable　operation　of　eco-friendly　apparatus　using　CF10O.　©　2020　IEEE.