It　is　a　long-pursued　goal　to　construct　various　smart　theranostics　nanoplatforms　by　facile　and　repeatable　method　for　personalized　tumor　treatment.　Herein,　we　employed　novel　alkyne-phenol　and　alkyne-amine　click-reaction　to　fabricate　responsively　biodegradable　and　multimodal　polymeric　nanoplatforms　for　magnetic　resonance　imaging　(MRI)　guided　effective　chemotherapy.　The　antitumor　drug　doxorubicin　(DOX)　and　some　essential　amino　acid　such　as　lysine　could　react　with　trimethylolpropane　tripropiolate　(TMP)　in　a　quite　mild　conditions　(room　temperature　and　weak　alkaline)　by　facile　click-reactions　to　give　polyprodrugs,　the　carboxyl　and　excess　amino　groups　on　LTD　tended　to　further　coordinate　with　Mn2+　to　afforded　metal-coordinated-polyprodrugs　(termed　as　LTD@Mn2+).　The　resulting　LTD@Mn2+　nanoparticles　have　high　covalently　drug　loading　ratio　(up　to　35%),　and　could　effectively　and　responsively　release　DOX　and　Mn2+　in　the　acidic　environment　of　tumor　cells　(extracellular　pH　~6.8,　endosomes　and　lysosomes　pH　~5.0),　because　the　resulting　vinyl-ether　and　vinyl-amino　bonds　in　LTD@Mn2+　are　stable　in　neutral　physiological　environment　but　tend　to　be　broken　in　acidic　conditions.　The　smart　LTD@Mn2+　nanoplatforms　not　only　showed　significant　tumor　inhibit　efficiency　and　negligible　damage　to　normal　tissues　both　in　vitro　and　in　vivo　due　to　the　high　drug　loading　ratio　and　controlled　release　properties,　but　also　provided　satisfied　MRI　quality　for　assessment　the　treatment　effect　because　of　the　magnetic　nature　of　Mn2+.　Thus,　the　metal-ligated　polyprodrug　suggests　a　new　strategy　for　the　simple　and　repeatable　preparation　of　polyprodrugs　for　precise　and　personalized　treatment　of　tumors.　©　2021　Elsevier　B.V.