Thermochemical　approaches　of　oxidizing　NO　to　NO2　have　been　considered　as　the　critical　steps　governing　NOx　purification　technologies.　However,　developing　efficient　materials　with　boosted　NO　oxidation　activity　and　strong　SO2　resistance　at　low　temperature　still　remains　a　significant　challenge.　This　contribution　discloses　a　versatile　and　scalable　methodology　for　the　design　of　hollow　MnO2@CeO2　heterostructures　for　NO　oxidation.　Due　to　its　hollow　core-shell　nanostructure　with　a　high　density　of　active　oxygen　vacancies　and　improved　charge-transfer　efficiency　induced　by　the　heterojunction　interface,　the　resulting　material　exhibits　remarkable　lowtemperature　catalytic　activity　in　NO　oxidation　(T-50　at　196　degrees　C　and　T-92　at　275　degrees　C),　achieving　over　69　degrees　C　of　temperature　reduction　in　comparison　with　the　commercial　Pt/　Al2O3　catalyst　(T-50　at　275　degrees　C).　Remarkably,　the　SO2　tolerance　of　the　hollow　core-shell　material　is　greatly　enhanced　due　to　the　block　accessibility　of　the　mesoporous　CeO2　shell　(E-CeO2,E-SO2　=　-1.78　eV　vs　E-MnO2,E-SO2　=　-1.04　eV).　This　work　exemplifies　an　alternative　perspective　in　the　design　of　high-performance　hollow　core-shell　nanostructured　catalysts　for　atmospheric　pollutant　purification　and　industrial　thermal　catalysis　processes.