Biodegradable　elastomers　are　attractive　in　soft　tissue　regeneration　due　to　their　biomimetic　viscoelastic　properties　and　biocompatibility.　However,　conventional　elastomers　are　inherently　weak　and　lack　the　bioactivity　required　for　highly　efficient　tissue　regeneration.　Silica-based　biomaterials　have　shown　high　mechanical　stiffness　and　special　bioactivities　including　stimulating　osteogenesis　and　angiogenesis　by　enhancing　corresponding　gene　expressions.　Here,　by　a　facile　polymerization,　we　synthesized　a　series　of　silica　grafted　poly　(1,8-octanediol-co-citrate)　(SPOC)　hybrid　elastomers　with　highly　tunable　physicochemical　properties　and　bioactivities.　The　silica　phase　was　successfully　grafted　to　the　side　chain　of　POC.　The　silica　phase　incorporation　significantly　endowed　POC　elastomers　with　highly　controlled　thermal　stability,　mechanical　properties,　hydrophilicity,　biodegradation　and　biocompatibility.　The　tensile　strength,　initial　modulus　and　elongation　of　SPOC　hybrid　elastomers　were　highly　tunable　and　range　from　2-15　MPa,　4-25　MPa　and　50-140%　respectively,　which　is　almost　a　four-fold　enhancement　compared　with　pure　POC　elastomers.　In　addition,　SPOC　elastomers　significantly　enhanced　the　proliferation　and　metabolic　activities　of　multiple　cell　lines　including　the　adipose-derived　stem　cells,　fibroblasts,　myoblasts　and　osteoblasts,　indicating　their　high　biocompatibility.　These　optimized　structures　and　properties　of　the　silica-grafted　hybrid　elastomers　make　them　promising　for　soft　and　hard　tissue　regeneration　applications.