The　development　of　combined　heat　and　power　(CHP)　systems　based　on　the　supercritical　carbon　dioxide　(SCO2)　Brayton　cycle　is　important　to　enhance　the　energy　utilization　efficiency　and　satisfy　different　energy　demands.　Therefore,　this　study　summarizes　and　compares　the　SCO2　CHP　configurations　in　terms　of　back-pressure　heating　(system　without　pre-cooler　(PC))　and　extraction　heating　CHP　types　(system　with　PC).　The　configurations　proposed　in　previous　studies　and　new　configurations　proposed　in　this　work　are　involved.　Thermodynamic　analysis　models　are　developed,　and　the　genetic　algorithm　is　used　to　optimize　the　multi-parameters　of　SCO2　CHP　configurations　to　reach　the　highest　exergy　efficiency.　For　the　back-pressure　CHP　type,　the　configuration　based　on　the　SCO2　recompression–reheat　cycle　has　the　highest　exergy　efficiency　of　44.1%,　which　can　generate　219.5　MW　of　power　under　the　selected　heat　load　of　300　MW.　For　the　extraction　CHP　type,　the　demands　of　300　MW　heat　and　315　MW　electricity　are　selected　as　the　comparison　condition.　Under　the　comparison　condition,　the　energy　and　exergy　efficiencies　of　the　configuration　E-2　proposed　in　this　study　are　respectively　73.9%　and　40.8%.　The　configuration　E-2　is　integrated　by　the　recompression-intercooling　cycle,　high-pressure　extraction　heating　and　reheat.　Moreover,　exergy　losses　and　destruction　within　the　SCO2　CHP　system　are　analyzed　to　reveal　its　energy-saving　mechanism　in　this　study.　©　2021