We　study　the　effects　of　strain　and　oxygen　vacancy　on　the　electronic　structure　of　the　(SrMmO3)2/(LaAlO3)2.5　heterostructure　based　on　the　first-principles　calculations　of　density　functional　theory.　The　results　show　that　different　strains　change　the　occupation　of　the　eg　orbitals　of　Mn,　which　makes　the　system　have　different　magnetic　ground　states　and　electronic　properties.　It　is　also　found　that　the　conductivity　of　the　(SrMmO3)2/(LaAlO3)2.5　system　increases　with　the　increase　of　oxygen　vacancies　rate,　which　can　be　used　for　the　new　generation　electronic　devices.　©　2021