Background:　Crohn＇s　disease　(CD)　is　a　clinically　chronic　inflammatory　bowel　disease,　which　has　been　shown　to　be　closely　related　to　the　brain-gut　axis　dysfunction.　Although　traditionally　considered　to　be　a　limbic　region,　the　insula　has　also　been　commonly　identified　as　an　abnormal　brain　region　in　previous　CD-related　studies.　Methods:　Structural　magnetic　resonance　imaging　(MRI)　and　resting-state　functional　MRI　images　were　acquired　from　45　CD　patients　in　remission　and　40　healthy　controls　(HCs).　Three　neuroimaging　analysis　methods　including　voxel-based　morphometry　(VBM),　structural　covariance,　and　functional　connectivity　(FC)　were　applied　to　investigate　structural　and　functional　alterations　of　the　insulae　between　the　CD　patients　and　HCs.　Pearson　correlation　was　then　used　to　examine　the　relationships　between　neuroimaging　findings　and　clinical　symptoms.　Results:　Compared　with　the　HCs,　CD　patients　exhibited　decreased　gray　matter　volume　(GMV)　in　the　left　dorsal　anterior　insula　(dAI)　and　bilateral　posterior　insula　(PI).　Taking　these　three　areas　including　the　left　dAI,　right　PI,　and　left　PI　as　regions　of　interest　(ROIs),　differences　were　observed　in　the　structural　covariance　and　FC　of　the　ROI　with　several　regions　between　the　two　groups.　After　controlling　for　psychological　factors,　the　differences　of　several　regions　involved　in　emotional　processing　in　GMV　in　the　left　dAI,　the　FC　of　the　dAI,　and　the　right　PI　were　not　significant.　The　FC　of　the　parahippocampus/hippocampus　with　dAI　and　PI　were　negatively　correlated　with　the　CD　activity　index　(CDAI).　Conclusions:　We　suggest　that　the　insula-centered　structural　and/or　functional　changes　may　be　associated　with　abnormal　visceral　sensory　processing　and　related　emotional　responses　in　CD　patients.