Salusin　beta　is　a　multifunctional　bioactive　peptide　and　is　considered　as　a　promising　candidate　biomarker　for　predicting　atherosclerotic　cardiovascular　diseases.　The　present　study　was　designed　to　investigate　the　roles　and　mechanisms　of　salusin　beta　in　the　paraventricular　nucleus　(PVN)　in　attenuating　hypertension　and　hypothalamic　inflammation　and　whether　central　salusin　beta　blockade　has　protective　effects　in　essential　hypertension.　Normotensive　Wistar-Kyoto　(WKY)　rats　and　spontaneously　hypertensive　rats　(SHR)　were　used　in　this　study.　The　rats　were　chronic　PVN　infusion　either　specific　salusin　beta　blocker,　antisalusin　beta　IgG　(SIgG),　or　control　IgG　(CIgG)　for　2　weeks.　Hypertensive　rats　had　significantly　increased　salusin　beta　expression　compared　with　normotensive　rats.　Central　blockade　of　salusin　beta　attenuated　hypertension,　reduced　circulating　norepinephrine　(NE)　levels,　and　improved　cardiac　hypertrophy　and　function　in　hypertensive　rats.　Salusin　beta　blockade　significantly　reduced　proinflammatory　cytokines　(PICs),　nuclear　factor-kappa　B　(NF-kappa　B)　activity,　reactive　oxygen　species　(ROS)　levels,　and　altered　renin-angiotensin　system　(RAS)　components　in　the　PVN　of　hypertensive　rats.　These　findings　suggest　that　the　beneficial　effects　of　salusin　beta　blockade　in　essential　hypertension　are　possibly　due　to　down-regulate　of　inflammatory　molecules　and　ROS　in　the　PVN.