OBJECTIVE:　Since　little　has　been　reported　about　Guillain-Barre　syndrome　(GBS)　after　spine　surgery,　we　sought　to　determine　some　of　the　clinical　features　and　the　management　of　the　condition.　METHODS:　A　total　of　4　cases　of　GBS　after　spine　surgery　were　included.　The　medical　charts　of　the　patients　were　reviewed　to　obtain　demographic　and　clinical　details.　All　the　patients　underwent　neurologic　and　electrophysiologic　examinations　and　were　followed　up　after　surgery.　RESULTS:　The　onset　of　symptoms　about　GBS　was　2-7　days　after　the　operation.　Neurologic　evaluation　showed　weaknesses　of　upper　and　lower　extremities　and　repeal　of　tendon　reflexes.　The　patients　exhibited　typical　clinical　symptoms　and　signs　of　GBS　and　electromyographic　findings.　Lumbar　puncture　was　performed　in　2　cases,　and　cerebrospinal　fluid　examination　showed　albuminocytological　dissociation.　All　the　4　patients　were　diagnosed　as　GBS　on　the　basis　of　typical　clinical,　laboratory,　and　electrophysiologic　findings.　Intravenous　immunoglobulin　was　instituted.　At　follow-up,　one　patient　needed　ventilator　support;　one　patient　could　transfer　from　bed　to　chair;　one　walked　with　assistive　devices;　and　the　remaining　patient　had　residual　minor　neurologic　deficits.　CONCLUSIONS:　These　cases　warn　surgeons　to　be　alert　to　the　association　of　GBS　and　spine　surgery.　On　the　basis　of　our　experience,　we　recommend　consideration　of　this　rare　diagnosis　in　patients　with　paralysis　after　spine　surgery.