Nonsteroidal　anti-inflammatory　drugs　(NSAIDs)　are　emerging　organic　pollutants　in　aquatic　systems.　Although　their　removal　is　essential,　it　remains　challenging.　In　the　present　study,　mesoporous　PCN-777(Zr),　PCN-333(Cr),　and　PCN-333(Fe)　were　constructed　and　then　applied　for　exploring　their　adsorption　performances　for　indomethacin　sodium　(IDM),　diclofenac　sodium　(DCF),　and　ketoprofen　(KTF).　In　comparison　to　PCN-333(Fe),　PCN-777(Zr)　and　PCN-333(Cr)　exhibited　much　higher　adsorption　capacities　of　IDM,　DCF,　and　KTF,　thus　they　were　selected　as　adsorbents　for　the　subsequent　investigations.　Then　we　evaluated　their　adsorption　kinetic　and　isotherm　features,　which　could　be　well　described　by　pseudo-second-order　kinetic　and　Langmuir　isotherm　models.　Especially　for　IDM　molecules,　PCN-777(Zr)　and　PCN-333(Cr)　displayed　adsorption　capacities　of　793.6　and　806.5　mg·g–1,　ranking　first　among　various　previously　reported　adsorbents.　Furthermore,　the　thermodynamics　parameters　confirmed　the　endothermic　and　spontaneous　adsorption　processes.　Effects　of　pH　on　the　adsorbent　surface　charges　and　the　NSAIDs　adsorption　capacities　were　examined　in　order　to　uncover　the　possible　mechanisms　behind　the　present　adsorption　process.　The　synergy　effects　of　electrostatic　interactions,　H-bond　interactions,　and　π-π　stackings　may　contribute　to　the　decontamination　of　IDM,　DCF,　and　KTF.　The　coexisting　salt　ions　and　organic　impurities　were　insensitive　to　IDM,　DCF,　and　KTF　removal.　Both　adsorbents　also　exhibited　satisfactory　reproducibilities　after　five　consecutive　adsorption-desorption　cycles.　The　adsorbents　reported　herein　could　be　exploited　as　a　promising　protocol　for　the　treatment　of　NSAIDs-contaminated　effluents.　©　2022　Elsevier　B.V.