A　micro　two-stage　axial　flow　cyclone　was　developed　with　guide　vane　in　series　in　front　of　the　dry　gas　seal　filter　to　pre-separate　the　liquid　and　solid.　The　effects　of　vane　blade　outlet　angle　and　wrap　angle　on　the　performance　were　verified　by　experiments,　and　then　two-stage　axial　cyclones　were　optimized.　Furthermore,　the　optimized　two-stage　axial　flow　cyclone　was　applied　to　the　dry　gas　seal　system　of　high-pressure　natural　gas　compressor,　and　the　performance　was　tested　under　7.21–7.80　MPa.　The　results　show　that　the　vane　blade　outlet　angle　of　the　second　stage　is　smaller　than　that　of　the　first　stage,　while　the　vane　blade　wrap　angle　is　larger.　The　two-stage　cyclone　can　separate　smaller　droplets,　and　the　separation　efficiency　increases　by　10%.　Under　the　high-pressure　conditions,　the　separation　efficiencies　of　the　cyclone　are　more　than　65%,　and　the　cumulative　efficiency　of　1.5　μm　droplet　is　more　than　90%.　©　2021　Elsevier　Ltd