Hypertension　is　one　of　the　main　factors　of　cardiovascular　disease　worldwide　and　is　strongly　related　to　the　overall　mortality.　High　salt　intake　is　a　major　risk　factors　for　hypertension.　Identifying　functional　foods　that　can　help　prevent　mechanistic　abnormalities　mediating　salt-induced　hypertension　is　an　issue　of　considerable　nutraceutical　and　scientific　interest.　Dietary　Momordica　charantia　may　be　an　alternative　approach　to　avoid　salt-induced　hypertension.　Dahl　salt-sensitive　(DSS)　rats　were　used　to　determine　whether　Momordica　charantia　water　extracts　(ME)　exerts　anti-hypertensive　effects　in　the　present　study.　ME　gavage　could　significantly　prevented　the　increase　of　blood　pressure,　blood　urea　nitrogen,　creatinine,　and　urine　protein-to-creatinine　ratio　of　DSS　rats.　Metabolomics　analysis　indicated　that　high-salt　diet　induced　abnormal　amino　acid　metabolism　was　related　to　nitric　oxide　(NO)　deficiency,　but　ME　gavage　could　upregulate　the　activities　of　nitric　oxide　synthase,　aspartate　aminotransferase,　argininosuccinate　lyase,　argininosuccinate　synthase　and　restore　endogenous　synthesis　of　arginine　and　NO.　Meanwhile,　renal　function　was　improved　after　ME　gavage.　Citrulline,　as　one　of　the　important　component　in　ME,　could　attenuate　salt-induced　hypertension　by　increasing　endogenous　synthesis　of　arginine　and　NO.　Antioxidants　in　ME,　such　as　phenolic　compound,　may　avoid　high-salt　induced　oxidative　stress　in　DSS　rats,　which　may　be　another　mechanism　by　which　ME　prevented　blood　pressure　increase.　Thus,　the　present　study　indicated　that　feeding　Momordica　charantia　could　avoid　high-salt-induced　hypertension　in　DSS　rats.