Mixed　oxide　(MO)　with　localized　growth　feature　and　high　growth　rate　remarkably　affects　the　lifetime　of　thermal　barrier　coatings　(TBCs),　which　indicates　that　clarifying　the　ceramic　cracking　mechanism　induced　by　MO　is　critical　for　developing　new　coatings　with　high　durability.　Two　kinds　of　TBC　models　involving　spherical　and　layered　mixed　oxides　are　created　to　explore　the　influence　of　MO　growth　on　the　local　stress　state　and　crack　evolution　during　thermal　cycle.　The　growth　of　α-Al2O3　is　also　included　in　the　model.　The　undulating　interface　between　ceramic　coat　and　bond　coat　is　approximated　using　a　cosine　curve.　Dynamic　ceramic　cracking　is　realized　by　a　surface-based　cohesive　interaction.　The　ceramic　delamination　by　simulation　agrees　with　the　experimental　observation.　The　effects　of　MO　coverage　ratio　and　growth　rate　on　the　TBC　failure　are　also　discussed.　The　results　show　that　the　MO　growth　causes　the　local　ceramic　coat　to　bear　the　normal　tensile　stress.　The　failure　mode　of　coating　is　turned　from　α-Al2O3　thickness　control　to　MO　growth　control.　Once　the　mixed　oxide　appears,　local　ceramic　cracking　is　easy　to　occur.　When　multiple　cracks　connect,　ceramic　delamination　happens.　Suppressing　MO　formation　or　decreasing　MO　growth　can　evidently　improve　the　coating　durability.　These　results　in　this　work　can　provide　important　theoretical　guidance　for　the　development　of　anti-cracking　TBCs.　©　2022　Elsevier　Ltd　and　Techna　Group　S.r.l.