Lead-free　piezoelectric　material-based　ultrasonic　transducers　have　been　researched　for　several　years,　but　the　inefficient　properties　and　design　difficulties　have　troubled　lead-free　ultrasonic　transducers　for　a　long　time.　To　improve　the　performance　and　design　efficiency　of　lead-free　ultrasonic　transducers,　in　this　work,　an　equivalent　circuit　model　and　intelligent　optimization　algorithm　were　combined　for　use　in　a　transducer　design.　Firstly,　0.94(Bi0.5Na0.5)TiO3-0.06BaTiO3(BNT-6BT)　lead-free　piezoelectric　ceramics　were　prepared　and　characterized.　Then,　BNT-6BT　ceramics　were　used　to　fabricate　the　ultrasonic　transducers.　An　equivalent　circuit　model-based　software,　PiezoCAD,　and　a　genetic　algorithm-based　back-propagation　neural　network　were　used　to　optimize　the　design　of　the　transducers.　A　3.03　MHz　center　frequency　and　60.3%　−6　dB　bandwidth　of　the　optimized　transducers　were　achieved,　which　were　consistent　with　the　neural　networks　optimization　results.　To　verify　the　application　potential　of　the　lead-free　transducers,　tungsten　rods　phantom　imaging　and　polystyrene　spheres　with　300　μm　diameter　manipulation　were　completed　by　the　transducers,　and　the　experiment　results　indicate　that　the　BNT-6BT　lead-free　transducers　have　great　potential　in　further　biological　and　biomedical　applications.　©　2022　by　the　authors.