Background:　SPOCK2　is　a　member　of　the　SPOCK　family,　a　424-amino　acid　protein　that　binds　to　glycosaminoglycans　to　form　proteoglycans.　The　purpose　of　this　study　was　to　explore　expression　profile　of　SPOCK2,　and　evaluate　prognostic　potential　and　its　correlation　with　immune　infiltration　in　high-grade　serous　ovarian　cancer　(HGSOC).　Methods:　Expression　of　SPOCK2　mRNA　and　protein　between　normal　and　tumor　tissues　were　analyzed　using　the　Cancer　Genome　Atlas　database　(TCGA),　Gene　Expression　Omnibus　(GEO),　Clinical　Proteomic　Tumor　Analysis　Consortium　(CPTAC),　and　the　Human　Protein　Atlas　(HPA)　databases.　Receiver　operating　characteristic　(ROC)　curve　was　used　to　evaluate　diagnostic　performance　of　SPOCK2.　Kaplan-Meier　method　and　Cox　regression　analysis　were　conducted　to　assess　the　effect　of　SPOCK2　on　survival.　Nomogram　was　used　to　predict　the　impact　of　SPOCK2　on　prognosis.　LinkedOmics　were　used　to　find　correlated　genes　and　perform　functional　enrichment　analyses.　The　relationships　between　SPOCK2　and　tumor　infiltrating　lymphocytes　(TILs)　were　determined　by　tumor-immune　system　interaction　database　(TISIDB)　and　GSVA　package　(V1.34.0).　Results:　SPOCK2　was　highly　expressed　in　HGSOC　tissue　compared　to　normal　tissue　at　both　mRNA　(p　＜　0.001)　and　protein　(p　=　0.03)　levels.　The　area　under　the　curve　(AUC)　is　0.894　(CI:　0.865-0.923).　Kaplan-Meier　analysis　showed　that　HGSOC　patients　with　high-level　SPOCK2　mRNA　expression　had　a　worse　overall　survival　(OS)　than　those　with　a　low　expression　(HR　=　1.45,　p　=　0.005).　Univariate　logistic　regression　analysis　found　that　age,　primary　therapy　outcome,　tumor　status,　tumor　residual,　and　SPOCK2　expression　level　were　significantly　associated　with　OS　(p　＜　0.05).　The　nomogram　model　indicated　an　effective　predictive　performance　of　SPOCK2.　Kyoto　encyclopedia　of　genes　and　genomes　(KEGG)　and　gene　ontology　(GO)　term　analyses　showed　that　SPOCK2　were　mainly　involved　in　regulating　extracellular　matrix.　Immune　infiltration　analysis　showed　that　SPOCK2　may　correlate　with　abundance　of　TILs.　Conclusion:　SPOCK2　has　potentials　to　estimate　diagnosis　and　prognosis　for　HGSOC　and　is　involved　in　regulating　extracellular　matrix　and　immune　cell　infiltration.