Introduction　This　study　explored　cannabis　use　for　pain　relief　among　socially　marginalised　Nigerian　women　in　the　context　of　barriers　to　pain　management.　Methods　The　study　was　designed　as　a　qualitative　exploratory　study　of　pain　experience　and　management.　Sixteen　in-depth,　individual　interviews　were　conducted　with　street-involved　women　who　use　drugs　and　had　chronic　pain.　Transcripts　were　coded　and　analysed　thematically.　Results　Pain　was　experienced　as　a　pervasive　feature　of　everyday　life　that　disrupted　daily　routines,　affected　economic　activities,　strained　social　relationships　and　had　adverse　effects　on　health　and　wellbeing.　Participants　sought　treatment　in　health　facilities,　but　faced　social　and　health　system　barriers　to　service　utilisation　including　financial　cost　of　services,　dismissal　of　symptoms　by　providers,　stigma　due　to　physical　appearance,　substance　use　and　lack　of　social　support.　These　barriers　encouraged　disengagement　from　services　and　reliance　on　cannabis　(along　with　heroin　and　diverted　prescription　opioids)　for　pain　management.　Cannabis　use　relieved　pain　and　improved　daily　functioning,　enabling　participants　to　undertake　economic　activities.　However,　using　cannabis　to　enhance　the　effects　of　opioids　and　heavy　and　long-term　use　owing　to　pain　chronicity　and　disability　generated　concerns　about　harms.　Discussion　and　Conclusions　Findings　show　the　therapeutic　benefits　of　cannabis　in　the　face　of　barriers　to　pain　management.　This　support　calls　to　explore　the　potentials　of　cannabis　for　pain　management　for　socially　marginalised　populations　and　to　develop　medical　guidelines　to　reduce　the　risk　of　adverse　health　consequences.　Therapeutic　cannabis,　provided　based　on　medical　guidance,　could　improve　pain　management　for　socially　marginalised　populations.