The　increasing　penetration　of　renewable　energy　generation　(REG)　introduces　an　amount　of　uncertainty　and　power　electronics　devices　into　power　grid　that　severely　affects　the　physical　responses　in　the　evolution　of　cascading　failure.　However,　existing　cascading　failure　models　cannot　accurately　describe　the　physical　responses　affected　by　the　features　of　REG　and　their　interaction　in　the　propagation　of　cascading　failure.　In　this　paper,　a　cascading　failure　model　integrating　the　multiply　physical　responses　is　proposed.　In　this　model,　the　physical　responses　affected　by　REG　are　described,　including　relay　protection,　frequency　regulation　and　dispatching　strategy.　In　the　experiment,　our　model　is　compared　with　the　model　in　traditional　power　grid.　The　experimental　results　show　that　the　penetration　of　REG　will　change　the　evolution　path　of　failure,　and　the　probability　of　blackouts　will　increase　with　the　increasing　penetration　level　of　REG.　©　2022　IEEE.