Poly-and　perfluoro　alkyl　substances　(PFAS)　are　a　group　of　man-made,　notoriously　persistent,　and　highly　toxic　contaminants　in　the　environment　reported　worldwide.　Many　adsorbents　including　granular　acti-vated　carbon,　graphene,　biochar,　zeolites,　and　clay　minerals　have　been　tested　for　PFAS　removal　from　water,　but　most　of　these　materials　suffer　from　high　cost　and/or　poor　removal　performance.　Here,　we　syn-thesized,　characterized,　and　examined　the　efficiency　of　PCN-222(Fe),　a　new　porous　metal　organic　frame-work　(MOF)　with　high　water　stability,　for　adsorptive　removal　of　a　frequently　occurring　PFAS,　perfluorooctane　sulfonate　(PFOS),　from　water.　The　adsorption　isotherm　and　kinetic　studies　revealed　high　PFOS　adsorption　capacity　of　PCN-222　(2257　mg/g),　with　rapid　PFOS　removal　rate　(within　30　min).　The　structure　of　PCN-222　was　unaffected　in　water　in　the　pH　range　of　2-10　but　disintegrated　and　lost　its　PFOS　removal　ability　at　pH　＞　10.　The　PFOS　adsorption　on　PCN-222　was　an　endothermic　reaction.　Electrostatic　attraction　was　a　dominant　mechanism　for　PFOS　adsorption　at　＜　1694　mg/g　PFOS　concentra-tion,　while　hydrophobic　interaction　accompanied　with　hydrogen-bonding　was　responsible　at　＞=　1694　mg/　g　PFOS　concentration.　The　interlayer　morphology　of　PCN-222　did　not　change　due　to　increasing　PFOS　loading.　The　findings　of　this　study　demonstrated　superior　features　of　PCN-222　over　other　conventional　adsorbents　for　its　potential　application　in　removing　PFOS　from　contaminated　water　to　reduce　PFOS　trans-fer　from　water　to　living　organisms.(c)　2023　Published　by　Elsevier　Inc.