Fretting　corrosion　of　zirconium　(Zr)　alloy　fuel　rod　cladding　with　spacer　grid　will　occur　due　to　flow　induced　vibration　in　reactor.　The　corrosion　accelerated　wear　between　fuel　rod　cladding　and　spacer　grid　in　high　temperature　water　environment　has　not　been　considered　in　the　existing　research.　The　fretting　corrosion　behavior　of　Zr　alloy　cladding　in　different　potential　(–0.8　V,　–0.4　V,　0　V,　0.4　V,　and　0.8　V)　is　studied　by　fretting　wear　test　equipment　combined　with　electrochemical　workstation.　The　SEM,　EDS,　XPS,　EBSD,　and　3D　optical　microscope　are　used　to　obtain　the　information　of　morphology　and　surface　chemical　composition.　The　friction　oxidation　behavior　and　fretting　damage　mechanism　of　Zr　alloy　under　different　applied　potentials　are　studied.　The　results　show　that　the　corrosion　current　in　the　fretting　process　increases　with　the　increase　of　potential,　which　accelerates　the　oxidation　corrosion　of　Zr　alloy　in　the　wear　process　and　aggravates　the　fretting　damage.　The　obvious　furrows　and　oxide　particles　accumulated　on　the　surface　of　wear　scar　in　different　potential　is　observed.　The　main　wear　mechanism　is　abrasive　wear　and　oxidation　wear.　The　wear　depth　and　wear　rate　of　Zr　alloy　increase　with　the　increase　of　potential,　because　the　increase　of　potential　would　accelerate　corrosion　and　improve　the　interaction　between　wear　and　corrosion,　resulting　in　the　wear　rate　increasing.　The　effect　of　potential　on　the　wear　morphology,　wear　volume,　and　interaction　of　wear　and　corrosion　of　Zr　alloy　is　revealed.　The　wear　mechanism　of　Zr　alloy　under　different　potential　conditions　is　clarified,　and　this　paper　provides　the　theoretical　support　for　the　analysis　and　prediction　of　fretting　corrosion　behavior　of　Zr　alloy　in　long-term　operation　condition.　©　2022　Chinese　Mechanical　Engineering　Society.　All　rights　reserved.