Lipid　metabolism　may　be　involved　in　the　pathogenic　mechanism　of　age-related　macular　degeneration　(AMD).　However,　conflicting　results　have　been　reported　in　the　associations　of　AMD　with　blood　lipids.　We　performed　a　meta-analysis　including　a　total　of　19　studies　to　evaluate　associations　between　blood　lipids　and　this　disease.　The　result　reported　that　the　high　level　of　high-density　lipoprotein　cholesterol　(HDL-C)　obtained　with　an　increment　of　1　mmol/L　could　result　in　a　significantly　increase　in　the　AMD　risk　of　approximately　18%　(relative　risk　(RR),　1.18;　95%　confidence　interval　(CI),　1.01　to　1.35;　I-2　=　53.8%;　p　=　0.007).　High　levels　of　total　cholesterol　(TC),　low-density　lipoprotein　cholesterol　(LDL-C),　and　triglycerides　(TG)　were　significantly　associated　with　a　decreased　risk　of　AMD　(RRs　ranging　from　0.92　to　0.95;　all　p　＜　0.05).　The　stratified　analysis　based　on　AMD　subtypes　showed　that　these　blood　lipids　were　only　significantly　associated　with　the　risk　of　early　AMD　(all　p　＜　0.05).　The　association　between　the　blood　lipids　and　AMD　risk　did　not　differ　substantially　based　on　the　other　characteristics　of　the　participants.　A　high　HDL-C　level　was　associated　with　an　increased　AMD　risk,　whereas　participants　with　high　TC,　LDL-C,　and　TG　concentrations　may　show　a　decreased　risk　for　this　disease.　Further　well-designed　large　studies　are　warranted　to　confirm　the　conclusions.