As　an　inorganic　bone　graft,　the　traditional　bioglass　45S5　can　offer　good　bioactivity　for　osteogenesis.　Type　I　collagen　(Col-1)　can　mimic　the　organic　components　of　natural　bone　in　hybrid　materials.　Hence,　in　this　study,　biomimetic　hybrid　materials　[CBGM(Collagen　Bioactive　Glass　Morsels),　CBGM1,　CBGS　(Collagen　Bioactive　Glass　Strips)　and　CBGS1]　were　fabricated　using　45S5　granules　and　high　purity　Col-1　at　a　proportion　of　8.5:1.5.　The　surface　features　of　these　materials　were　observed　using　scanning　electron　microscopy　and　element　energy　dispersive　spectroscopic　(EDS).　The　activity　of　MC3T3-E1　cells,　including　adhesion,　proliferation　and　gene　expression,　was　significantly　improved　in　the　CBGS　and　CBGS1　groups　compared　with　the　45S5　group.　Additionally,　X-ray,　micro　computed　tomography,　EDS　and　histomorphology　showed　that　these　hybrid　materials　had　significantly　enhanced　osteogenesis　and　degradation　6　and　12　weeks　after　implantation　in　rabbit　femoral　condylar　defects　compared　with　45S5.　CBGS　and　CBGS1　were　significantly　better　than　CBGM　and　CBGM1　in　terms　of　osteogenesis　and　degradability.　Consequently,　with　the　improved　osteogenesis　and　the　faster　degradation　rate,　the　hybrid　materials　CBGS　and　CBGS1　are　promising　bone　graft　candidates　for　clinical　application.　(C)　2016　Elsevier　Ltd.　All　rights　reserved.