Purpose:　Tumor　associated　macrophages　(TAMs)　are　important　prognostic　factors　and　have　been　proved　to　be　associated　with　the　invasion　and　migration　of　various　cancer.　However,　the　relationship　between　TAMs　and　breast　cancer　outcomes　remains　unclear.　Experimental　Design:　Sixteen　studies　with　a　total　of　4,541　breast　cancer　patients　were　included　in　this　meta-analysis.　Correlation　of　TAMs　with　overall　survival　(OS),　disease-free　survival(DFS),　relapse-free　survival　(RFS),　breast　cancer　special　survival　(BCSS)　and　clinicopathological　features　were　analyzed.　Survival　data　and　clinicopathological　value　were　integrated　by　analyzing　hazard　ratio(HR)　and　odds　ratio(OR)　separately　and　using　Fixed-effect　or　Random-effect　model　according　to　heterogeneity.　All　statistical　tests　were　two-sided.　Results:　OS　and　DFS　were　correlated　with　high　density　of　TAMs　with　HR=1.504(1.200,　1.884)/2.228(1.716,　2.892)　respectively.　And　subgroup　analysis　of　location　and　biomarker　in　OS　and　DFS　group　showed　prognosis　was　associated　with　TAMs　distribution　and　biomarker　selection.　Besides,　TAMs　high　infiltration　was　significantly　related　to　age,　size,　histologic　grade,　ER/PR　status,　basal　phenotype　and　vascular　invasion.　Conclusion:　High　density　of　TAMs　was　associated　with　poor　survival　rates　of　breast　cancer.　TAMs　in　stroma　are　associated　with　worse　outcome　than　that　in　nest　and　using　CD68　as　a　biomarker　for　TAMs　to　evaluate　the　risk　is　better　than　CD163　or　CD206　alone.　Moreover,　high　infiltration　of　TAMs　was　significantly　associated　with　negative　hormone　receptor　status　and　malignant　phenotype.　TAMs　infiltration　can　serve　as　a　novel　prognostic　factor　in　breast　cancer　patients.