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Author:

Chai, Hua (Chai, Hua.) | Li, Zi-na (Li, Zi-na.) | Meng, De-yu (Meng, De-yu.) (Scholars:孟德宇) | Xia, Liang-yong (Xia, Liang-yong.) | Liang, Yong (Liang, Yong.)

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SCIE PubMed Scopus

Abstract:

Gene selection is an attractive and important task in cancer survival analysis. Most existing supervised learning methods can only use the labeled biological data, while the censored data (weakly labeled data) far more than the labeled data are ignored in model building. Trying to utilize such information in the censored data, a semi-supervised learning framework (Cox-AFT model) combined with Cox proportional hazard (Cox) and accelerated failure time (AFT) model was used in cancer research, which has better performance than the single Cox or AFT model. This method, however, is easily affected by noise. To alleviate this problem, in this paper we combine the Cox-AFT model with self-paced learning (SPL) method to more effectively employ the information in the censored data in a self-learning way. SPL is a kind of reliable and stable learning mechanism, which is recently proposed for simulating the human learning process to help the AFT model automatically identify and include samples of high confidence into training, minimizing interference from high noise. Utilizing the SPL method produces two direct advantages: (1) The utilization of censored data is further promoted; (2) the noise delivered to the model is greatly decreased. The experimental results demonstrate the effectiveness of the proposed model compared to the traditional Cox-AFT model.

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Author Community:

  • [ 1 ] [Chai, Hua; Xia, Liang-yong; Liang, Yong] Macau Univ Sci & Technol, Fac Informat Technol, Ave Wai Long, Taipa 999078, Macao, Peoples R China
  • [ 2 ] [Chai, Hua; Xia, Liang-yong; Liang, Yong] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Ave Wai Long, Taipa 999078, Macao, Peoples R China
  • [ 3 ] [Li, Zi-na; Meng, De-yu] Xi An Jiao Tong Univ, Inst Informat & Syst Sci, Xian 710049, Shaanxi, Peoples R China
  • [ 4 ] [Li, Zi-na; Meng, De-yu] Xi An Jiao Tong Univ, Minist Educ, Key Lab Intelligent Networks & Network Secur, Xian 710049, Shaanxi, Peoples R China
  • [ 5 ] [Chai, Hua]Macau Univ Sci & Technol, Fac Informat Technol, Ave Wai Long, Taipa 999078, Macao, Peoples R China
  • [ 6 ] [Xia, Liang-yong]Macau Univ Sci & Technol, Fac Informat Technol, Ave Wai Long, Taipa 999078, Macao, Peoples R China
  • [ 7 ] [Liang, Yong]Macau Univ Sci & Technol, Fac Informat Technol, Ave Wai Long, Taipa 999078, Macao, Peoples R China
  • [ 8 ] [Chai, Hua]Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Ave Wai Long, Taipa 999078, Macao, Peoples R China
  • [ 9 ] [Xia, Liang-yong]Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Ave Wai Long, Taipa 999078, Macao, Peoples R China
  • [ 10 ] [Liang, Yong]Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Ave Wai Long, Taipa 999078, Macao, Peoples R China
  • [ 11 ] [Li, Zi-na]Xi An Jiao Tong Univ, Inst Informat & Syst Sci, Xian 710049, Shaanxi, Peoples R China
  • [ 12 ] [Meng, De-yu]Xi An Jiao Tong Univ, Inst Informat & Syst Sci, Xian 710049, Shaanxi, Peoples R China
  • [ 13 ] [Li, Zi-na]Xi An Jiao Tong Univ, Minist Educ, Key Lab Intelligent Networks & Network Secur, Xian 710049, Shaanxi, Peoples R China
  • [ 14 ] [Meng, De-yu]Xi An Jiao Tong Univ, Minist Educ, Key Lab Intelligent Networks & Network Secur, Xian 710049, Shaanxi, Peoples R China

Reprint Author's Address:

  • Macau Univ Sci & Technol, Fac Informat Technol, Ave Wai Long, Taipa 999078, Macao, Peoples R China.; Liang, Y (reprint author), Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Ave Wai Long, Taipa 999078, Macao, Peoples R China.

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Source :

SCIENTIFIC REPORTS

ISSN: 2045-2322

Year: 2017

Volume: 7

4 . 1 2 2

JCR@2017

4 . 3 7 9

JCR@2020

ESI Discipline: MULTIDISCIPLINARY;

ESI HC Threshold:196

JCR Journal Grade:4

CAS Journal Grade:3

Cited Count:

WoS CC Cited Count: 11

SCOPUS Cited Count: 17

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 3

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