Purpose:　As　a　promising　photodynamic　therapy　(PDT)　agent,　Al(III)　phthalocyanine　chloride　tetrasulfonic　acid　(AlPcS4)　provides　deep　penetration　into　tissue,　high　quantum　yields,　good　photostability,　and　low　photobleaching.　However,　its　low　delivery　efficiency　and　high　binding　affinity　to　serum　albumin　cause　its　low　penetration　into　cancer　cells,　further　limiting　its　PDT　effect　on　gastric　cancer.　In　order　to　improve　AlPcS4/PDT　effect,　the　AlPcS4　delivery　systems　with　different　drug　carriers　were　synthesized　and　investigated.　Materials　and　methods:　Gold　nanorods,　cationic　liposomes,　and　Pluronic　(R)　F127　nanomicellars　were　used　to　formulate　the　AlPcS4　delivery　systems.　The　anticancer　effect　was　evaluated　by　CCK-8　assay　and　colony　formation　assay.　The　delivery　efficiency　of　AlPcS4　and　the　binding　affinity　to　serum　proteins　were　determined　by　fluorescence　intensity　assay.　The　apoptosis　and　necrosis　ability,　reactive　oxygen　species　and　singlet　oxygen　generation,　mitochondrial　transmembrane　potential　and　([Ca2+](i))　concentration　were　further　measured　to　evaluate　the　mechanism　of　cell　death.　Results:　The　series　of　synthesized　AlPcS4　delivery　systems　with　different　drug　carriers　improve　the　limited　PDT　effect　in　varying　degrees.　In　contrast,　AlPcS4　complex　with　gold　nanorods　has　significant　anticancer　effects　because　gold　nanorods　are　not　only　suitable　for　AlPcS4　delivery,　but　also　exhibit　enhanced　singlet　oxygen　generation　effect　and　photothermal　effect　to　induce　cell　death　directly.　Moreover,　AlPcS4　complex　with　cationic　liposomes　shows　the　potent　inhibition　effect　because　of　its　optimal　AlPcS4　delivery　efficiency　and　ability　to　block　serum　albumin.　In　addition,　AlPcS4　complex　with　Pluronic　F127　exhibits　inferior　PDT　effect　but　presents　lower　cytotoxicity,　slower　dissociation　rate,　and　longer　retention　time　of　incorporated　drugs;　thus,　F127-AlPcS4　is　used　for　prolonged　gastric　cancer　therapy.　Conclusion:　The　described　AlPcS4　drug　delivery　systems　provide　promising　agents　for　gastric　cancer　therapy.