Objective:　To　investigate　the　effect　of　octanoic　acid　(OA)　on　the　peripheral　component　of　tremor,　as　well　as　OA＇s　differential　effects　on　the　central　and　peripheral　tremor　component　in　essential　tremor　(ET)　patients.　Methods:　We　analyzed　postural　tremor　accelerometry　data　from　a　double-blind　placebo-controlled　crossover　study　evaluating　the　effect　of　4　mg/kg　OA　in　ET.　The　weighted　condition　was　used　to　identify　tremor　power　for　both　the　central　and　peripheral　tremor　components.　Exploratory　non-parametric　statistical　analyses　were　used　to　describe　the　relation　between　the　central　and　peripheral　component　of　tremor　power.　Results:　A　peripheral　tremor　component　was　identified　in　4　out　of　18　subjects.　Tremor　power　was　reduced　after　OA　administration　in　both　the　central　and　the　peripheral　tremor　component.　There　was　a　positive　correlation　of　tremor　power　between　the　central　and　peripheral　component,　both　after　placebo　and　OA.　Conclusions:　When　present,　the　peripheral　component　was　closely　related　to　the　central　tremor　component.　We　hypothesize　that　the　magnitude　of　the　peripheral　mechanical　component　of　tremor　is　determined　by　that　of　the　central　component.　Significance:　Both　central　and　peripheral　component　of　tremor　are　reduced　after　OA,　with　the　central　component　providing　the　energy　driving　the　peripheral　component.　(C)　2018　Published　by　Elsevier　B.V.　on　behalf　of　International　Federation　of　Clinical　Neurophysiology.