Background:　Functional　dyspepsia　(FD)　is　a　common　upper　gastrointestinal　disorder　worldwide,　but　the　current　treatments　for　FD　are　still　unsatisfactory.　The　aims　of　this　study　were　to　investigate　the　efficacy　and　safety　of　Qi-Zhi-Wei-Tong　granules　in　patients　with　postprandial　distress　syndrome　(PDS)-predominant　FD.　Methods:　The　study　was　conducted　as　a　randomized,　double-blinded,　multicenter,　placebo-controlled　design　in　197　patients　with　PDS.　All　participants　received　placebo　treatment　for　1　week.　Patients　whose　total　symptom　score　decreased　by　＜50%　after　the　placebo　treatment　were　recruited　into　the　4-week　treatment　period,　in　which　they　were　randomly　assigned　to　be　treated　with　either　Qi-Zhi-Wei-Tong　granules　or　placebo.　The　patients　were　then　followed　for　2　weeks　without　any　treatment.　Dyspeptic　symptoms　were　scored　at　weeks　2　and　4　during　the　random　treatment　period　and　2　weeks　after　the　treatment.　Anxiety　and　depression　symptoms　were　also　scored　and　compared.　Results:　(1)　The　total　effective　rates　in　the　Qi-Zhi-Wei-Tong　granules　group　at　weeks　2　and　4　during　the　random　treatment　period　and　2　weeks　after　treatment　were　all　significantly　higher　than　those　in　the　placebo　group　(38.82%　vs.　8.75%,　P　＜　0.001;　69.14%　vs.　16.25%,　P　＜　0.001;　77.65%　vs.　21.25%,　P　＜　0.001).　(2)　The　total　dyspeptic　symptoms　scores　in　the　Qi-Zhi-Wei-Tong　granules　group　at　weeks　2　and　4　and　2　weeks　after　treatment　were　significantly　lower　than　those　in　the　placebo　group.　(3)　The　severity　and　frequency　of　each　dyspeptic　symptom　at　weeks　2　and　4　and　the　follow-up　period　were　all　significantly　lower　than　those　in　the　placebo　group.　(4)　The　anxiety　scores　in　the　Qi-Zhi-Wei-Tong　granules　group　were　significantly　lower　than　those　in　the　placebo　group.　(5)　Qi-Zhi-Wei-Tong　granules　did　not　have　more　adverse　effects　than　the　placebo.　Conclusion:　Qi-Zhi-Wei-Tong　granules　offer　significant　symptomatic　improvement　in　PDS　with　no　more　adverse　effects　than　placebo.