The　poor　cell　membrane　penetration　ability　of　photosensitizers　resulted　in　the　limited　antitumor　effect,　thereby　hampered　their　potential　in　clinical　translation.　The　high　toxic　side　effect　and　multidrug　resistance　of　chemotherapeutic　agents　during　in　clinical　chemical　therapy　should　be　resolved.　Nanosystem　integrated　with　photosensitizer　and　novel　targeting　chemotherapy　agent　may　be　an　effective　strategy　for　overcoming　clinical　or　preclinical　drawbacks　of　monotherapy　and　enhancing　therapeutic　effect.　Therefore,　a　nanosized　micelle　F127　integrated　with　Apogossypolone　(ApoG(2))　and　Al(III)　phthalocyanine　chloride　tetrasulfonic　acid　(AlPcS4)　(referred　as　F127-ApoG(2)@AlPcS4)　was　synthesized　to　induce　the　cell　death　quickly　for　reducing　the　risk　of　resistance　and　enhancing　gastric　cancer　therapeutic　efficiency　by　combining　AlPcS4/photodynamic　therapy　and　ApoG(2)/chemotherapy.　Hydrophobic　of　ApoG(2)　and　hydrophilic　of　AlPcS4　self-assembled　into　this　micelle　to　formation　of　core-shell　structure　based　on　the　amphiphilic　character　of　F127　micelle.　The　reactive　oxygen　species-dependent　mitochondria　membrane　permeability　was　improved　effectively　because　of　reactive　oxygen　species　generation　of　ApoG(2),　thereby　resulting　in　a　considerable　amount　of　AlPcS4　and　ApoG(2)　entering　the　mitochondrial.　The　AlPcS4　binding　site　was　altered　from　the　cytoplasm　to　the　cell　nucleus　at　higher　concentration　because　of　the　existence　of　ApoG(2).　With　irradiation,　ApoG(2)　and　AlPcS4　showed　effective　synergistic　anti-tumor　effect　through　inducing　apoptosis　due　to　singlet　oxygen　production　regulated　mainly　by　AlPcS4,　reactive　oxygen　species　accumulation　and　calcium　overload　regulated　mainly　by　ApoG(2).　Intranuclear　AlPcS4　caused　cell　death　through　necrosis.　The　apoptosis　induced　by　AlPcS4　was　earlier　than　ApoG(2).　In　summary,　F127-ApoG(2)@AlPcS4　quickly　induced　a　long-lasting　apoptosis　that　led　to　cell　death,　which　could　be　a　promising　nanosized　reagent　for　gastric　cancer　therapy　based　on　chemo-photodynamic　combined　therapy.