Mechanotransduction　enables　cells　to　translate　external　forces　and　physical　constraints　into　biochemical　signals　controlling　multiple　aspects　of　cell　behavior.　Methodologies　mimicking　various　mechanical　and　biomedical　forces　exposed　to　cells,　have　been　proposed　to　investigate　cell　mechanotransduction.　However,　it　is　still　a　great　challenge　developing　platform　towards　dynamically　multivariate　mechanical　stimulation　addressing　individual　cells　or　small　colonies　of　cells.　A　photomechanical　and　biocompatible　platform　for　extracellular　mechanical　stimuli　is　constructed　by　soft　bilayer　nanocomposites　composed　of　polydimethylsiloxane　(PDMS)　and　PDMS/GNPs　(graphene　nanoplatelets).　The　fast　backlash　bending　process　can　give　rise　to　mechanical　stimuli　to　the　cells　growing　on　it　in　a　controllable　manner　by　near　infrared　(nIR)　irradiation.　Beneficial　from　the　excellent　controllability　in　nIR　light　intensity　and　working　frequency,　the　backlash　bending　velocity,　acceleration,　frequency,　as　well　as　sophisticated　bending　process　can　be　well　controlled,　thus　extracellular　mechanical　forces　even　predesigned　loading　cycles　can　be　realized.　SGC-7901　cells　viability,　one　of　the　lines　in　highest　incidence　Gastric　cancer　in　almost　Asian　countries,　can　be　restricted　by　our　proposed　platform.　It　will　not　only　provide　a　solution　for　studying　cell　mechanotransduction　with　more　complicated　force　conditions,　but　also　demonstrate　a　promising　methodology　supplementing　the　physical　therapy　for　fighting　against　the　malignant　tumor.　(C)　2018　Elsevier　Ltd.　All　rights　reserved.