To　determine　the　priority　hazard　in　drinking　water,　disability-adjusted　life　years　(DALYs)　method　was　used　to　evaluate　the　disease　burden　induced　by　trihalomethanes　(THMs)　and　low-level　arsenic　through　multiple　exposure　routes　based　on　the　two-year　sampling　from　drinking　water　in　Xi＇an　city,　Northwest　China.　The　average　concentrations　of　chloroform　(TCM),　bromodichloromethane　(BDCM),　dibromochloromethane　(DBCM),　bromoform　(TBM)　and　arsenic　were　12.67 μg/L,　1.42 μg/L,　0.60 μg/L,　0.13 μg/L　and　1.00 μg/L,　respectively,　and　the　total　lifetime　cancer　risks　for　all　THMs　and　arsenic　were　8.54 × 10＜sup＞-6＜/sup＞　and　4.02 × 10＜sup＞-5＜/sup＞,　which　were　8.54　and　40.2　times　of　the　negligible　risk　level　(1.00 × 10＜sup＞-6＜/sup＞),　respectively.　The　DALYs　estimation　showed　that　the　total　DALYs　lost　for　all　age　groups　was　32.62　person-year,　and　the　average　individual　DALYs　lost　was　4.77 × 10＜sup＞-6＜/sup＞　per　person-year　(ppy),　which　was　4.77　times　of　the　reference　level　(1.00 × 10＜sup＞-6＜/sup＞　ppy).　About　72.07%　of　the　total　disease　burden　was　due　to　arsenic,　which　was　considered　to　be　the　priority　hazard　in　Xi＇an　drinking　water.　The　age　group　of　75-80　years　was　found　to　be　most　vulnerable　to　the　induced　cancer　risk,　and　skin　cancer　had　the　highest　disease　burden　(2.24 × 10＜sup＞-6＜/sup＞　ppy).　Due　to　the　relatively　high　incidence　rates　of　lung　cancer　and　skin　cancer,　most　DALYs　lost　for　males　were　2-4　times　to　that　for　females　in　the　same　age　group.　Oral　ingestion　made　the　most　contribution　(88.58%)　to　the　total　disease　burden,　followed　by　inhalation　of　THMs　(11.30%),　whereas　dermal　absorption　showed　negligible　risk　(0.12%).　As　the　first　to　compare　the　cancer　risks　of　arsenic　and　THMs　to　the　public　in　DALYs　in　China,　this　study　might　be　useful　for　potential　strategies　of　risk　control　and　management　of　hazardous　agents　in　drinking　water.