Previous　studies　showed　that　EGR3　gene　located　in　chromosome　8p21.3　was　involved　in　the　etiology　of　schizophrenia.　However,　the　finding　failed　to　be　replicated　in　several　case-control　studies.　To　investigate　the　genetic　role　of　the　EGR3　gene　in　Chinese　psychiatric　patients,　we　genotyped　five　single　nucleotide　polymorphisms　(SNPs)　in　EGR3　gene　locus　using　93　nuclear　families　in　Han　Chinese,　and　performed　transmission　disequilibrium　test　(TDT).　In　this　study,　two　SNPs　(rs1996147　and　rs3750192)　showed　significant　association　with　schizophrenia　(c2＞4.40,　P＜0.05).　In　the　linkage　disequilibrium　analysis,　the　significant　association　was　also　found　in　two-　(rs3750192-rs35201266),　three-　(rs1877670-　rs3750192-rs7009708)　and　four-SNP　(rs1996147-rs1877670-rs3750192-rs7009708)　tests　of　haplotype　analyses　(c2＞7.10,　global　P＜0.05).　Overall,　the　results　suggested　that　EGR3　gene　may　play　an　important　role　in　schizophrenia　susceptibility　in　the　Han　Chinese　population,　and　further　functional　exploration　of　the　EGR3　gene　will　contribute　to　the　underlying　molecular　mechanism　for　schizophrenia　pathogenesis.