Objective:　To　investigate　the　Malytea　Scurfpea　fruit　(MSF)　on　melanocyte　adhesion　and　migration.　Method:　Human　epidermal　melanocytes　were　treated　with　MSF　and　Ginger　respectively,　then　adhesion　to　bovine　serum　fibronectin-coated　culture　dishes　was　checked.　Control　and　treated　cells　were　also　examined　for　migration　into　micropore　filters　coated　with　the　same　protein.　Result:　Compared　with　control,　MSF　treated　melanocytes　were　obviously　easier　to　adhere　to　the　dishes　and　move　into　the　filters　in　a　dose-dependent　manner.　When　the　dose　of　MSF　was　200　mg·L-1,　it　could　not　reincrease　melanocyte　adhesion　and　migration.　At　10　mg·L-1,　under　every　other　concentrations　of　MSF,　there　was　no　marked　difference　among　MSF-treated,　Ginger-treated　and　untreated　melanocytes　(P　＜　0.05)　when　adhesion　test　were　studied.　But　to　migration,　even　at　10　mg·L-1　MSF,　there　was　obvious　increased　migration　compared　with　MSF-untreated　or　Ginger-treated　melanocytes　(P　＜　0.01).　Conclusion:　MSF　has　effect　on　melanocyte　adhesion　and　migration,　which　can　explain,　in　part,　the　capacity　of　MSF　to　modulate　melanocyte　function　in　vitiligo　lesions.