Objective:　To　investigate　the　interaction　between　terbinafine　and　fluconazole　or　itraconazole　against　Candida　albicans.　Methods:　The　minimum　inhibitory　concentrations　(MIC)　of　36　clinical　isolates　of　Candida　albicans　from　genital　locus　was　determined　by　broth　microdilution　method　recommended　by　NCCLS.　A　checkerboard　microdilution　method　was　used　to　study　the　in　vitro　interaction　of　terbinafine　with　fluconazole　or　itraconazole.　Results:　The　incidence　of　Candida　albicans　resistant　isolates　were　8.33%　(fluconazole),　11.11%　(itraconazole)　and　16.67%　(terbinalfine).　The　geometric　mean　MIC　of　terbinafine　combinated　with　fluconazole　was　significantly　lower　than　that　of　the　single　agent　(t　=　3.590,　P＜0.05;　t　=　3.25,　P＜0.05).　Forty-two　percent　(15/36)　of　interactions　were　synergy,　fifty　percent　(18/36)　additive,　and　eight　percent　(3/36)　indifferent.　Terbinafine　in　combination　with　itraconazole　significantly　reduced　the　geometric　mean　MIC　than　the　single　agent　(t　=　3.849,　P＜0.001;　t　=　2.409,　P＜0.05).　39%　(14/36)　of　interactions　were　synergy,　47%　(17/36)　were　additive,　and　14%　(5/36)　were　indifferent.　Antagonism　was　not　observed　in　any　drug　combination.　Conclusions:　The　combination　of　terbinafine　with　either　fluconazole　or　itraconazole　can　produce　synergism　and　/or　addition　in　most　strains　of　Candida　albicans　in　vitro.