A　systematized　calculation　of　foaming　parameters　in　producing　microcellular　polymethyl　methacrylate　(PMMA)　with　supercritical　carbon　dioxide　(SCCO2)　was　proposed.　The　calculated　optimal　results　were　saturation　temperature　=　313　K,　pressure　=　25　MPa　and　time　=　15　h,　which　were　achieved　by　the　Chow　model,　classical　nucleation　theory　and　Fick　diffusion　law,　respectively.　Additionally,　the　Center-Composite　Design　(CCD)　statistical　approach　in　Response　Surface　Method　(RSM)　was　employed　to　evaluate　the　validity　of　the　calculated　parameters.　The　error　between　the　optimal　parameters　predicted　by　CCD　statistical　approach　and　the　calculated　ones　was　acceptable,　demonstrating　the　accuracy　of　the　calculated　parameters.　©Smithers　Information　Ltd.　2016.