With　the　rapid　development　of　active　implanted　medical　devices,　the　communication　between　in　vivo　implants　has　aroused　the　interest　of　researchers.　How　to　achieve　bidirectional　communication　between　multiple　implants　in　the　body　with　limited　volume　and　power　consumption　becomes　a　challenge　in　biomedical　engineering.　This　paper　designs　and　implements　a　method　of　communication　between　in　vivo　implants　based　on　low-power　Bluetooth　4.0,　which　can　establish　bidirectional　stable　communication　between　one　master　and　eight　slave　nodes.　The　master　and　slave　circuits,　which　are　exactly　the　same,　uses　commercial　components　with　the　volume　only　21mm　×　10mm　×　2mm.　Through　testing,　in　the　connection　state　during　master　cycle　(T　=　1s)　with　the　slave　sending　data　and　without　other　peripherals,　the　operating　current　of　the　master　is　80　uA　and　the　slave　is　154　uA,　which　basically　meets　the　needs　of　communication　between　implants　in　vivo.　Moreover,　the　circuit　structure　could　be　further　optimized　and　compacted,　which　means　the　volume　and　power　consumption　of　the　communication　board　may　be　further　reduced.　©　2017　IEEE.