The　precaution　and　treatment　for　cancer　become　inevitable　with　the　rising　of　morbidity　and　mortality.　In　this　article,　a　promising　new　methodology　for　cancer　treatment,　sono-dynamic　therapy　(SDT)　was　introduced.　In　addition,　we　extensively　reviewed　the　molec-ular　mechanisms　of　SDT　killing　cancer　and　summarized　the　classification　of　sonosensi-tizers.　At　the　same　time,　research　progress　of　SDT　indicates　that　it　is　possible　to　become　a　developing　field　for　cancer　treatment　in　clinical　application.