©　2016,　Editorial　Board　of　Journal　of　Xi＇an　Jiaotong　University　(Medical　Sciences).　All　right　reserved.　Objective:　To　evaluate　IL-1β　and　TNF-α　levels　in　the　serum　of　Kaschin-Beck　disease　(KBD)　patients　with　Meta-analysis.　Methods:　The　literature　on　detection　of　IL-1β　and　TNF-α　levels　in　KBD　patients　was　comprehensively　searched　and　qualified　articles　were　selected　based　on　inclusion　and　exclusion　criteria　using　RevMan　5.2　software　for　Meta-analysis.　Results:　We　included　8　articles　involving　totally　291　KBD　patients　and　300　healthy　controls.　IL-1β　level　was　significantly　higher　in　the　KBD　patients　than　in　the　healthy　controls　(SMD=1.55,　95%　CI=0.73-2.37,　P＜0.000　01).　TNF-α　level　in　the　KBD　patients　was　also　significantly　higher　than　that　in　the　healthy　controls　(SMD=2.49,　95%　CI=1.49-3.49,　P＜0.000　01).　Conclusion:　IL-1β　and　TNF-α　levels　in　KBD　patients　are　significantly　increased,　but　their　role　in　KBD　development　still　requires　further　study.