©　2017,　Scientific　Publishers　of　India.　All　rights　reserved.　Objective:　To　investigate　the　epidemiology　and　influential　factors　of　nosocomial　pulmonary　infection　in　type　2　diabetes　mellitus　(T2DM)　patients　complicated　with　malignancies.　Methods:　316　T2DM　patients　complicated　with　malignancies　in　our　hospital　were　selected　as　the　research　objects　from　February　2015　to　June　2017.　Among　them,　36　cases　had　pulmonary　infection　in　the　hospital.　We　firstly　investigated　the　epidemiology,　then　Pearson　correlation　analysis　and　multivariate　logistic　regression　analysis　were　adopted　respectively　to　analyze　the　related　factors　of　nosocomial　pulmonary　infection　in　T2DM　patients　complicated　with　malignancies.　Results:　According　to　the　epidemiological　investigation,　in　T2DM　patients　complicated　with　malignancies,　the　nosocomial　pulmonary　infection　rate　in　aged　patients　(≥　60　years　old)　was　significantly　higher　than　that　in　younger　patients　(＜60　years　old,　P＜0.05);　the　infection　rate　in　male　patients　was　significantly　higher　than　that　in　female　patients　(P＜0.05);　the　longer　course　of　diabetes,　the　higher　rate　of　nosocomial　pulmonary　infection　(P＜0.05);　the　higher　of　the　BMI　level,　the　higher　rate　of　nosocomial　pulmonary　infection　(P＜0.05);　the　infection　rate　in　rural　patients　was　significantly　higher　than　that　in　city　patients　(P＜0.05);　the　infection　rate　in　manual　workers　was　significantly　higher　than　that　in　mental　workers　(P＜0.05);　the　higher　level　of　education,　the　lower　rate　of　nosocomial　pulmonary　infection　(P＜0.05);　no　significant　relationship　was　found　between　fasting　plasma　glucose　(FPG)　level　and　nosocomial　pulmonary　infection　rate　(P＞0.05).　Through　Pearson　correlation　analysis　and　multivariate　logistic　regression　analysis,　we　finally　got　the　related　factors　of　nosocomial　pulmonary　infection　in　T2DM　patients　complicated　with　malignancies,　including　age,　impaired　respiratory　function,　and　chronic　diseases.　Conclusion:　The　nosocomial　pulmonary　infection　in　T2DM　patients　complicated　with　malignancies　had　a　certain　epidemiological　characteristics　and　was　affected　by　age,　impaired　respiratory　dysfunction　and　chronic　diseases　and　effective　measures　should　be　taken　to　prevent　it.