©　2017,　West　China　University　of　Medical　Science.　All　rights　reserved.　Objective　To　systematically　evaluate　the　efficacy　and　safety　of　Jinghua　Weikang　(JHWK)　capsules　plus　proton　pump　inhibitor　(PPI)-based　triple　regimen　in　the　treatment　of　Helicobacter　pylori　(Hp)　associated　chronic　gastritis　or　peptic　ulcer.　Methods　We　searched　CNKI,　VIP,　WanFang　Data,　CBM,　PubMed,　EMbase,　The　Cochrane　Library　(Issue　6,2016)　from　inception　to　July　2016,　to　collect　randomized　controlled　trials　(RCTs)　about　JHWK　capsules　plus　PPI-based　triple　regimen　(JPTR)　for　the　treatment　of　Hp　associated　chronic　gastritis　or　peptic　ulcer.　Two　reviewers　independently　screened　literatures　according　to　the　inclusion　and　exclusion　criteria,　extracted　data　and　assessed　the　risk　of　bias　of　included　studies.　Then　meta-analysis　was　performed　by　using　RevMan　5.3　software.　Results　Twenty　RCTs　were　finally　included,　involving　2　301　patients.　The　results　of　meta-analyses　showed:　①　JPTR　vs.　PPI-based　triple　regimen:　the　JPTR　group　had　higher　eradication　rate　of　Hp　(RR=1.21,　95%CI　1.12　to　1.31,　P＜0.001),　remission　of　gastrointestinal　symptom　(RR=1.07,　95%CI　1.03　to　1.11,　P=0.001)　and　the　healing　of　peptic　ulcer　(RR=1.18,　95%CI　1.07　to　1.30,　P=0.000　9),　and　lower　adverse　reactions　rate　(RR=0.52,　95%CI　0.36　to　0.75,　P＜0.001)　than　that　of　the　control　group.　②　JPTR　vs.　bismuth-containing　quadruple　therapy:　No　significant　differences　between　both　groups　in　Hp　eradication　rate　and　the　remission　of　gastrointestinal　symptom　(RR=0.96,　95%CI　0.86　to　1.07,　P=0.47;　RR=1.09,　95%CI　0.93　to　1.28,　P=0.30),　but　the　JPTR　group　had　lower　adverse　reactions　rate　than　that　of　the　bismuth-containing　quadruple　therapy　group　(RR=0.32,　95%CI　0.15　to　0.72,　P=0.005).　Conclusion　Current　evidence　shows　that　JPTR　is　superior　to　PPI-based　triple　regimen　in　Hp　eradication　rate,　the　remission　of　gastrointestinal　symptom,　the　healing　of　peptic　ulcer,　and　safety.　However,　JPTR　is　not　superior　to　the　bismuth-containing　quadruple　therapy　in　eradication　rate　of　Hp,　which　may　be　related　to　the　insufficient　sample　size.　Because　of　the　limitation　of　methodological　quality　of　the　included　studies　and　sample　size,　multicenter,　high-quality　RCTs　with　large　sample　are　required　to　prove　the　above　conclusion.