©　2018,　Editorial　Board　of　Journal　of　Xi＇an　Jiaotong　University　(Medical　Sciences).　All　right　reserved.　Objective:　To　establish　Metrigel-VEGF-SW982　complexes　and　use　the　complexes　to　produce　animal　models　of　synovial　sarcoma　so　as　to　provide　new　ideas　for　establishing　other　models　of　soft　tissue　tumors.　Methods:　After　the　SW982　cells　were　cultured　and　collected,　they　were　resuspended　with　Metrigel,　and　VEGF　was　added.　The　suspension　was　seeded　into　transwell　to　establish　the　scaffold　complexes　of　Metrigel-VEGF-SW982.　The　complexes　were　cultured　overnight.　Cryosections　were　made　and　HE　staining　was　carried　out　to　observe　the　cell　scaffold　complexes.　We　randomly　divided　10　female　SCID　mice　(4　week　old)　into　scaffold　group　and　control　group.　The　mice　in　the　scaffold　group　were　transplanted　with　cell-scaffold　complexes,　and　the　control　group　with　cell　suspension.　After　8　weeks,　the　success　rate　of　modeling　was　compared　between　two　groups.　The　mice　were　sacrificed　and　the　tumors　were　obtained.　HE　staining　was　carried　out　to　observe　the　histopathological　features　of　tumors　in　both　scaffold　group　and　control　group.　Results:　The　SW982　cells　were　cultured　with　Matrigel　in　a　3D　way,　which　could　simulate　the　growth　condition　of　cells　in　vivo.　Establishing　synovial　sarcoma　animal　model　with　cell　scaffold　complex　could　increase　the　success　rate.　The　tumors　in　scaffold　group　had　a　larger　volume,　higher　density　of　tumor　cells　and　greater　vascularization　(P＜0.05).　Conclusion:　Establishing　synovial　sarcoma　animal　model　with　Metrigel-VEGF-SW982　complex　can　greatly　improve　the　success　rate　of　modeling,　which　can　provide　basis　for　the　study　of　synovial　sarcoma.