Given　the　biological　function　of　SOX6　and　recent　genome-wide　association　finding,　we　performed　a　fine-mapping　association　analyses　to　investigate　the　relationship　between　SOX6　and　BMD　both　in　Caucasian　and　Chinese　populations.　We　identified　many　single-nucleotide　polymorphisms　(SNPs)　within　or　near　the　SOX6　gene　to　be　significantly　associated　with　hip　bone　mineral　density　(BMD).　SOX6　gene　is　an　essential　transcription　factor　in　chondrogenesis　and　cartilage　formation.　Recent　genome-wide　association　studies　(GWAS)　detected　a　SNP　(rs7117858)　located　at　the　downstream　of　SOX6　significantly　associated　with　hip　BMD.　Given　the　biological　function　of　SOX6　and　the　GWAS　finding,　we　considered　SOX6　as　a　new　candidate　for　BMD　and　osteoporosis.　Therefore,　in　this　study,　we　performed　a　fine-mapping　association　analyses　to　investigate　the　relationship　between　SNPs　within　and　near　the　SOX6　gene　and　BMD　at　both　hip　and　spine.　A　total　of　301　SNPs　were　tested　in　two　independent　US　Caucasian　populations　(2,286　and　1,000　unrelated　subjects,　respectively)　and　a　Chinese　population　(1,627　unrelated　Han　subjects).　We　confirmed　that　the　previously　reported　rs7117858-A　was　associated　with　reduced　hip　BMD,　with　combined　P　value　of　2.45　x　10(-4).　Besides　this　SNP,　we　identified　another　19　SNPs　within　or　near　the　SOX6　gene　to　be　significantly　associated　with　hip　BMD　after　false　discovery　rate　adjustment.　The　most　significant　SNP　was　rs1347677　located　at　the　intron　3　(P　=　3.15　x　10(-7)).　Seven　additional　SNPs　in　high　linkage　disequilibrium　with　rs1347677　were　also　significantly　associated　with　hip　BMD.　SNPs　in　SOX6　showed　significant　skeletal　site　specificity　since　no　SNP　was　detected　to　be　associated　with　spine　BMD.　Our　study　identified　many　SNPs　in　the　SOX6　gene　associated　with　hip　BMD　even　across　different　ethnicities,　which　further　highlighted　the　importance　of　the　SOX6　gene　influencing　BMD　variation　and　provided　more　information　to　the　understanding　of　the　genetic　architecture　of　osteoporosis.