Background　Cardiac　resynchronization　therapy　(CRT)　with　biventricular　pacing　improves　cardiac　function,　functional　capacity　and　quality　of　life　in　selected　patients　with　heart　failure.　The　current　study　aimed　to　evaluate　the　efficacy　of　the　intracardiac　electrogram　(IEGM)-based　optimization　method,　QuickOpt　(TM),　in　Chinese　patients　treated　with　CRT.　Methods　Aortic　time　velocity　integrals　(AVTI)　achieved　at　the　sensed　atrioventricular　(AV),　paced　AV　and　interventricular　(VV)　interval　settings　recommended　by　both　QuickOpt　(TM)　and　standard　echocardiographic　optimization　were　measured　in　101　patients.　Consistency　and　the　strength　of　the　relationship　between　the　two　timing　cycle　optimization　methods　were　assessed　by　intra-class　correlation　coefficient　(ICC).　Results　The　ICC　showed　good　agreement　and　correlation　with　what　the　AVTI　achieved　at　the　optimal　sensed　AV　(ICC=0.9683　(0.9535-0.9785)),　paced　AV　(ICC=0.9642　(0.9475-0.9757))　and　VV　(ICC=0.9730　(0.9602-0.9817))　interval　settings　determined　by　the　two　optimization　methods.　The　average　time　required　by　echocardiographic　optimization　and　by　QuickOpt　(TM)　were　(78.32　+/-　32.40)　minutes　and　(1.98　+/-　1.64)　minutes　respectively　(P＜0.0001).　Conclusion　The　QuickOpt　(TM)　algorithm　provides　a　quicker,　simpler　and　reliable　alternative　to　the　standard　method　for　timing　cycle　optimization.　(ClinicalTrial.gov　Reference　Number:　NCT00918294)　Chin　Med　J　2012;125(3):428-433